Disclosure forms provided by the authors are available with the full text of this article at. In their consensus statement on hyperglycemic crises in adult patients with diabetes, kitabchi et al. This article provides a simple, practical approach to identifying simple acidbase disorders and their compensatory mechanisms. Physicians should be able to interpret acid base disorders problems by following a systematic four step approach. Abstract acidbase disorders can provide essential clues to underlying patient conditions. Fall dr fall is assistant professor of medicine, medical college of georgia school of medicine, and chief of nephrology, veterans affairs medical center, augusta, georgia. A quick stepwise approach that provides an individualized fluid plan for the patient is needed once it has been determined that fluid therapy may be beneficial. Most acidbase derangements do not benefit from specific correction of the abnormal ph. Thus, it is important when evaluating acidbase disorders to determine whether changes in p co 2 and hco 3. Metabolic acidosis and metabolic alkalosis objectives by the end of this chapter, you should be able to. Analysis of acidbase disorders in patients with chronic. Diagnosis is made by arterial blood gas interpretation.
Physiological approach to assessment of acid base disturbances. A stepwise approach to acidbase status interpretation. Acidbase disorders msd manual professional edition. Deviations of systemic acidity in either direction can impose adverse consequences and when severe can threaten life itself. Analysis of a patients acidbase disorder includes identification of the primary disorder, calculation of the anion gap ag, evaluation.
Sisson, md fast facts both an arterial blood gas and a basic metabolic panel are necessary to determine a patients acidbase status. Acidbase disorders made so easy even a caveman can do it lorraine r franzi, mshsm, rd, ldn, cnsd nutrition support specialist university of pittsburgh medical center pittsburgh, pa i. These conditions can be categorized as acidoses or alkaloses and have a respiratory or metabolic origin, depending on the cause of the imbalance. Simple algorithm of arterial blood gas analysis to ensure. Dr fall outlines a stepbystep approach to acidbase disorders, with em phasis on metabolic acidosis.
A stepwise approach to acidbase disorders practical patient evaluation for metabolic acidosis and other conditions pamela j. Although the chemicalbiochemical basis of abb is important, this article aims to share a practical and. Because of this, acidbase disorders can be intimidating for many healthcare professionals. The third step entails assessing the adequacy of the compensatory. Adhering to a system will allow you to identify the primary and compensatory process. Acidbase disorders frequently are encountered in the outpatient and especially in the inpatient setting. First, and most importantly, assessment of the patient must be completed to determine. Ikawalit approach to acid base disorders acidbase balance has earned a reputation as a difficult subject to understand. Understanding acidbase disorders ulster medical society. This article provides readers with a stepwise approach for assessing abgs, as well as offering actual case examples to familiarize the reader with the concepts of acidbase disorders. Always analyze acidbase disturbance with both abg and venous electrolyte panel bmp 2. Approach to acidbase disorders a clinical chemistry.
The traditional approach we used in groups 1 and 3 table 1 was. The differential diagnosis, clinical findings, investigations, and treatments of hypercalcemia are discussed in this chapter. Although i appreciated their contribution of case studies and statistical analysis, i am in. Stepwise approach to interpreting the arterial blood gas. The physiological approach uses the carbonic acid bicarbonate buffer system. In mixed acidbase disorders deviations in pco2 and hco3. Stepwise approach to analysis of acidbase disorders 1. Open access simple algorithm of arterial blood gas analysis to ensure consistent, correct and quick responses. As with reading an electrocardiogram or a chest xray, it is important to use a system when reading arterial blood gases. For this purpose, a stepwise approach has been proposed by several authors 5053, and some simple concepts could help in supposing the presence of a mixed disorder. Acidbase homeostasis in man is accomplished by the maintenance of systemic arterial ph within a narrow range despite acid and alkaline loads originating from the daily intake and degradation of foods. A stepwise systematic approach can be used to determine the etiology and proper management of acidbase disorders. Clinical approach to patients with acidbase disorders. Clinical approach to patients with acidbase disorders thomas d.
Disorders of acidbase balance m aintenance of acidbase homeostasis is a vital function of the living organism. We will not consider the use of these calculated indices further in this article. Acidbase disorders in patients with chronic obstructive. Acidbase pathophysiology can be separated into metabolic or respiratory acidosis and alkalosis, as well as those disturbances that are compensated. Physiological approach to assessment of acidbase disturbances. Utilize a systematic approach to evaluate acid base disturbances.
Presented in a logical fashion, with proper attention paid to the basic physiologic and chemical principles involved, acid. Learning objectives the clinician after participating in the roundtable will be able to. Ryan killian, pharmd, bcps assistant professor clinical pharmacy. What i describe is the latest iteration of an approach we first described over 10 years ago4 and is built on the efforts of others. The third step in an evaluation is to consider the metabolic component of the acidbase disorder. The most clinical useful information comes from the clinical description of the patient by the history and physical examination. Acidbase disorders may occur as singular disorders, singular disorders with compensation, or a combination of disorders mixed acidbase disorders. Stepwise approach to interpreting the arterial blood gas 1.
An indepth knowledge of acidbase physiology is not essential for solving acidbase problems. Very often the presenting symptoms and signs give us a clue regarding the underlying acidbase disorder. Introduction disorders of acidbase balance can be found in as many as nine of every 10 patients in the icu, which means that acidbase disorders may be the most common clinical problems you will encounter in the icu. Approach to acidbase disorders a clinical chemistry perspective acidbase disorders are frequently encountered in clinical practice and have a significant impact on patient morbidity and mortality. The approach to identifying and managing acidbase disturbances should be a stepwise approach, as follows also see table 211. In these mixed disorders, values may be deceptively normal.
What is the likely clinical diagnosis based on history asa overdose mixed vomiting alkalosis copd with sepsis mixed resp and met acidosis copd with sepsis and vomiting triple acid base resp acidosis, gap acidosis and metabolic alkalosis copd with sepsis and diarrhea triple acid base. Complex acid base disturbances vanderbilt university medical. A practical approach to acidbase disorders that will help identify a majority of the disorders. Practical patient evaluation for metabolic acidosis and other conditions. We presume that the patient has sepsis, a disease associated with lactic acidosis and respiratory alkalosis. The following sixstep process helps ensure a complete interpretation of every abg. Acidbase disorders are easily characterized using a stepwise approach. Acutechronic phase only with respiratory disorders. Hyperglycemic crises in adult patients with diabetes. Understanding acidbase disorders a four step approach in order to understand the nature of an acidbase problem, we recommend a structured approach during which the following four questions should be asked. The corrected calcium is sufficient in most circumstances with acid base disorders and significantly altered albumin, the ionized calcium is more accurate.
First, identify the primary disturbance based on the ph of arterial blood to determine if it is acidemic or alkalemic. A stepwise approach for any acidbase problems in the step 2 ck exam 1. It is true that we did not use the approach suggested by dr bruno. Complex or mixed acidbase disturbances involve more than one primary process. No potential conflict of interest relevant to this article was reported. Acidbase disorders knowledge for medical students and. Acidbase disorders can usually be approached by following the steps outlined in the text and doing the calculations shown in the box on page 257. Pdf approach to acidbase disorders a clinical chemistry. Acidbase homeostasis is fundamental for maintaining life. This is followed by a discussion of primary respiratory acidosis and alkalosis and then metabolic causes of acidosis and alkalosis. For those who wish, a detailed discussion of it can be found in costanzo. Understand the clinical approach to acidbase disorders, including the basic equation, questions to ask about each disorder, the use of venous electrolytes, arterial blood gases, and the acidbase. Approach to acidbase disorders a clinical chemistry perspective.